Hypoallergenic Cotton Pajamas

Shop Pytona’s hypoallergenic cotton pajamas designed for breathability, moisture control, and skin-friendly wear. Durable and flexible styles made for restful nights and all-day comfort.

45 products
-40% • Price Drop
Pajama Set Cozy Sleep Home Lounging Cotton Ruffle 2 Piece
Pajama Set Cozy Sleep Home Lounging Cotton Ruffle 2 Piece

USD $250.33 USD $149.99

-37% • Price Drop
Lounge Set V-Neck Cotton Top & Pants for Relaxation
Lounge Set V-Neck Cotton Top & Pants for Relaxation

USD $79.73 USD $49.99

-25% • Price Drop
Pajama Set Cotton Floral Lounge Wear for Women
Pajama Set Cotton Floral Lounge Wear for Women
(60)

USD $81.83 USD $61.35

-22% • Price Drop
Cotton Lounge Pants - Breathable Home & Travel Wear
Cotton Lounge Pants - Breathable Home & Travel Wear

USD $37.61 USD $29.35

-25% • Price Drop
Leopard Print Ruffle Pajama Set for Women
Leopard Print Ruffle Pajama Set for Women

USD $44.39 USD $33.35

-26% • Price Drop
Comfortable Cotton Sleepwear Set for Women
Comfortable Cotton Sleepwear Set for Women

USD $47.93 USD $35.35

-25% • Price Drop
Women's Pure Cotton Pajamas with Floral Embroidery
Women's Pure Cotton Pajamas with Floral Embroidery

USD $49.90 USD $37.35

-26% • Price Drop
Cotton Buttoned Sleepwear Pajamas for Women
Cotton Buttoned Sleepwear Pajamas for Women

USD $55.94 USD $41.35

-22% • Price Drop
Comfortable Cotton Sleepwear Pajamas Dress
Comfortable Cotton Sleepwear Pajamas Dress

USD $42.58 USD $33.35

-25% • Price Drop
Cotton Knee-Length Sleepwear Pajamas Dress
Cotton Knee-Length Sleepwear Pajamas Dress

USD $39.06 USD $29.35

-41% • Price Drop
Comfortable Maternity Cotton Nightgown
Comfortable Maternity Cotton Nightgown

USD $61.12 USD $35.99

-25% • Price Drop
Cotton Knee-Length Sleepwear Pajamas
Cotton Knee-Length Sleepwear Pajamas

USD $55.06 USD $41.35

-24% • Price Drop
Chic Cotton Pajama Pants with Heart Print
Chic Cotton Pajama Pants with Heart Print

USD $27.94 USD $21.35

-31% • Price Drop
Breathable Cotton Lounge Sleepwear Pants with Pockets
Breathable Cotton Lounge Sleepwear Pants with Pockets

USD $28.89 USD $19.99

-37% • Price Drop
Boho Cotton Elastic Pants with Pockets – Fall Leaf Print
Boho Cotton Elastic Pants with Pockets – Fall Leaf Print

USD $44.74 USD $27.99

-37% • Price Drop
Cotton Puff Sleeve Lounge Set with Tie-Front Bow Top
Cotton Puff Sleeve Lounge Set with Tie-Front Bow Top

USD $60.11 USD $37.99

-24% • Price Drop
Women's Modal Pajama Set with Padded Tank
Women's Modal Pajama Set with Padded Tank

USD $61.90 USD $47.35

-26% • Price Drop
Women's Cotton Plaid Pajama Set with Shorts
Women's Cotton Plaid Pajama Set with Shorts

USD $52.84 USD $39.35

-25% • Price Drop
Floral Cotton Pajama Set for Cozy Nights
Floral Cotton Pajama Set for Cozy Nights

USD $52.62 USD $39.35

-25% • Price Drop
Ruffle Cotton Pajama Set for Women – Sleeveless Argyle Sleepwear
Ruffle Cotton Pajama Set for Women – Sleeveless Argyle Sleepwear

USD $36.27 USD $27.35

-31% • Price Drop
Cotton Dog Print Pajama Set with Notch Collar for Women
Cotton Dog Print Pajama Set with Notch Collar for Women

USD $43.73 USD $29.99

-26% • Price Drop
Notch Collar Cotton Pajama Set for Women – Soft Floral Sleepwear
Notch Collar Cotton Pajama Set for Women – Soft Floral Sleepwear

USD $45.18 USD $33.35

-26% • Price Drop
Women's Pajama Set - Cotton-Polyester Loungewear
Women's Pajama Set - Cotton-Polyester Loungewear
(2)

USD $63.63 USD $47.35

-28% • Price Drop
Casual Textured Lounge Nightgown Dress
Casual Textured Lounge Nightgown Dress
(7)

USD $46.34 USD $33.35

-36% • Price Drop
Women's Cotton Blend Stars Print Loungewear Shorts
Women's Cotton Blend Stars Print Loungewear Shorts

USD $24.80 USD $15.99

-34% • Price Drop
Comfy Tie-Dye Women’s Two-Piece Lounge Set
Comfy Tie-Dye Women’s Two-Piece Lounge Set

USD $36.22 USD $23.79

-39% • Price Drop
Casual Striped Lounge Pajama Set for Women
Casual Striped Lounge Pajama Set for Women

USD $65.03 USD $39.99

-31% • Price Drop
Floral Print Loungewear Set for Women | V Neck & Spaghetti Straps
Floral Print Loungewear Set for Women | V Neck & Spaghetti Straps

USD $31.24 USD $21.53

-37% • Price Drop
Cotton Plaid Lounge Set for Women
Cotton Plaid Lounge Set for Women

USD $41.18 USD $25.99

-31% • Price Drop
Spring Floral Print Fitted Cotton Blend Loungewear - Long Sleeve Crop Top & Shorts
Spring Floral Print Fitted Cotton Blend Loungewear - Long Sleeve Crop Top & Shorts

USD $29.18 USD $19.99

-40% • Price Drop
Ribbed Cotton Loungewear: Long Sleeve Top + Wide Leg Trousers
Ribbed Cotton Loungewear: Long Sleeve Top + Wide Leg Trousers

USD $36.64 USD $21.99

-38% • Price Drop
Essential Ribbed 2-Piece Loungewear - Cotton Blend Hooded Pullover and Pants
Essential Ribbed 2-Piece Loungewear - Cotton Blend Hooded Pullover and Pants

USD $38.24 USD $23.79

-24% • Price Drop
All-Season Heart Print Cotton Pajama Pants for Her
All-Season Heart Print Cotton Pajama Pants for Her

USD $30.84 USD $23.35

-24% • Price Drop
Botanical Print Women's Pajamas in 100% Cotton
Botanical Print Women's Pajamas in 100% Cotton

USD $49.45 USD $37.35

-27% • Price Drop
Floral Cotton Pajama Set - Ultimate Comfort
Floral Cotton Pajama Set - Ultimate Comfort

USD $43.24 USD $31.35

-22% • Price Drop
Casual Women's Pajamas - Cotton with Heart Motif
Casual Women's Pajamas - Cotton with Heart Motif

USD $40.14 USD $31.35